From Inventing a Breakthrough Asthma Inhaler to Tackling 100% Artery Blockages | Sarvajna Dwivedi
Podcasts > The Heart of Innovation with Kym McNicholas
Saturday, June 6, 2026
What does it take to go from helping millions of people breathe easier to helping patients keep their legs?
Join The Heart of Innovation as Kym McNicholas talks with Sarvajna Dwivedi, Ph.D., entrepreneur, inventor, and CEO of AngioSafe, whose career has spanned some of the most challenging problems in medicine.
Sarvajna co-founded Pearl Therapeutics, a company focused on breakthrough respiratory therapies that was ultimately acquired by AstraZeneca for $1.15 billion. Along the way, he helped develop inhaled therapies and drug-device combinations designed to improve the lives of patients with asthma and COPD. (AngioSafe United States)
Today, his focus has shifted from the lungs to the arteries.
As CEO and co-founder of AngioSafe, Sarvajna is leading the development of the Santreva-ATK Endovascular Revascularization Catheter, a novel device designed to restore blood flow through some of the most challenging chronic total occlusions (CTOs) physicians encounter in patients with peripheral artery disease (PAD). The technology is designed to cross completely blocked arteries, compress plaque, create a new channel, and restore blood flow without relying on a guidewire or external power source. (Medical Economics)
In this episode, we discuss:
• How a pharmaceutical scientist became a medical device innovator
• The story behind Pearl Therapeutics and its $1.15 billion acquisition
• Why chronic total occlusions remain one of the biggest challenges in PAD treatment
• How AngioSafe's Santreva-ATK technology works
• What it means to restore blood flow through arteries that are 100% blocked
• The future of cardiovascular and vascular innovation
If you or someone you love has peripheral artery disease, diabetes, leg pain while walking, non-healing wounds, or has been told an artery is completely blocked, this is a conversation you won't want to miss.
📞 Need help navigating PAD care? Call the Leg Saver Hotline: 1-833-PAD-LEGS
🌐 Learn more:
PADHelp.org
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@TheWayToMyHeart
👍 Like, subscribe, and share to help us spread awareness of PAD, a disease that is more prevalent and deadlier than many cancers combined, yet remains dramatically underdiagnosed.
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